Collaboration with VASA Therapeutics : characterization a heart failure model with preserved ejection fraction (HFpEF) / Dahl salt sensitive rats. Download all informations (pdf) Financial Disclosure Artur Plonowski, Benjamin Pratt, Magdalena Krupa, Piotr Lipiński, Christopher Larson, and Mark Herbert are employees and/or shareholders of Vasa Therapeutics. Role of MMP2,...
SYNCROSOME has acquired a new Echocardiograph Vivid™ S60 , GE Healthcare Logiciel version : R3 Probes : 12S-D and linear probe L8-18i-D Vivid™ S60 is used to measure cardiac morphological and functional parameters on anesthetized rats. Cardiovascular models : Myocardial ischemia Heart failure Heart aging Pulmonary arterial...
SYNCROSOME provides frozen or fixed slices of different tissues mounted on slides from several preclinical models. PAH models (Monocrotaline or SuHxNx) LUNGS and HEART (right and left ventricle) PLASMA samples HEART FAILURE models (Isoproterenol or Myocardial infarction) HEART (right and left ventricles) PARKINSON models (6-OHDA and Lactacystine): BRAIN ASTHMA...
The participation to the « Spring of Cardiology » offered to Syncrosome the opportunity to present its expertise in the cardiovascular field: development of preclinical models of heart failure and evaluation of cardiac remodelling and function by 2D-echocardiography to assess the efficacy of new therapeutic strategies. Since 2016,...
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. It results from a biphasic ischemia/reperfusion (I/R) injury to the heart. Despite considerable effort,...
Congestive heart failure (CHF) is a serious outcome of myocardial infarction (MI). Animal models have been used to study various aspects of CHF. Postinfarction animal models have been extensively studied because myocardial ischemia and infarction are frequent causes of CHF in humans. However, not all...
Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder characterized by progressive obliteration of small pulmonary arterioles that leads to increased pulmonary vascular resistance. Because of impaired blood flow inpulmonary arteries, right ventricular pressure (RVSP) rises, ultimately leading toright ventricular failure and premature death. This...
Myocardial infarction (MI) results from a biphasic ischemia/reperfusion (I/R) injury to the heart. The disease is linked to cardiomyocyte apoptosis and further along to inflammation-based tissue damage. Despite considerable effort, therapeutic interventions to disrupt this injury pattern are not optimal. Indeed, the inflammation's multifactorial nature complicates...
Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial obstruction increases pulmonary vascular resistance, leading to right ventricular hypertrophy (RVH), failure, and death. The development of small-animal preclinical models of PAH is a necessary challenge in order to test the efficacy of new...
Below a poster presented by Syncrosome during the last European Respiratory Society meeting showing interesting result concerning Pulmonary Arterial Hypertension induced on rats with Sugen with remodeling in small pulmonary arteries (PAH sugen). Results are reproducible and shows a vascular remodeling, increased Right Ventricular Systolic Pressure...